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Kan tages med eller uden mad. Kapslerne kan åbnes. Indholdet kan opslæmmes i vand eller kommes på på blød mad, fx yoghurt eller æblemos. Nedsat nyrefunktion cobicistat will raise the level or effect of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/keep an eye on carefully. A decreased dose of tramadol co